![肿瘤药物治疗方案及综合评价](https://wfqqreader-1252317822.image.myqcloud.com/cover/13/43604013/b_43604013.jpg)
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第五章 肺癌
第一节 小细胞肺癌
局限期小细胞肺癌同步放化疗中化疗方案
方案 EP方案*
![](https://epubservercos.yuewen.com/B8A9D8/22919013101368106/epubprivate/OEBPS/Images/T43_236_1442_1969_1890_79107.jpg?sign=1738828733-gNu6HFWnhk8J5YievzLYM9lpoylqtRYM-0-c406828b692e24e56e4fd89db4bc08f4)
*.该化疗方案与放疗同步应用,局限期SCLC患者胸部放疗总剂量为45Gy:1.5Gy/f,BID,共3周
方案评价
![](https://epubservercos.yuewen.com/B8A9D8/22919013101368106/epubprivate/OEBPS/Images/T43_228_2062_1966_2812_147338.jpg?sign=1738828733-JzGcQYKTG113GrRKsFtwXpOaYnUytJDM-0-6cdfc9cf15672d5e844302764db1d52f)
续表
![](https://epubservercos.yuewen.com/B8A9D8/22919013101368106/epubprivate/OEBPS/Images/T44_287_336_2028_1742_147341.jpg?sign=1738828733-WNeiJFJpwyhYBWwPMvrffmZ6bpn4rk06-0-56dd9018aedd945d6add173ce9c1348e)
点评
EP方案+同步放疗依然是治疗局限期小细胞肺癌的推荐方案(Ⅰ类)。证据来源为Ⅲ期多中心随机对照试验JCOG0202研究(NCT00144989)。适合ECOG 0~1分,20~70岁LS-SCLC患者。患者如果身体状态较差,不能耐受同步化放疗,也可行序贯化放疗。
(吴向华)
参考文献
[1] KUBOTA K,HIDA T,ISHIKURA S,et al.Etoposide and cisplatin versus irinotecan and cisplatin in patients with limited-stage small-cell lung cancer treated with etoposide and cisplatin plus concurrent accelerated hyperfractionated thoracic radiotherapy(JCOG0202):a randomised phase 3 study.Lancet Oncol,2014,15:106-113.